by Loren Pickart, Discoverer of GHK and many of its biological effects
BA Chemistry and Mathematics, University of Minnesota
PhD Biochemistry, University of California, San Francisco
- - - VIEW THE ORIGINAL THESIS ON GHK: "A TriPeptide From Human Serum" (June 1973)
Longer Telomeres Increase Cancer in Humans
There is an idea that longer telomeres in humans will extend the lifespan. However, the following study of 28,000 people over 22 years found that those with the longest telomeres have much higher rates of cancer.
From www.futurity.org
For the new study, researchers analyzed blood samples and health data on more than 28,000 Chinese people in the Singapore Chinese Health Study, which has followed the health outcomes of participants since 1993. As of the end of 2015, 4,060 participants had developed cancer.
Participants were divided into five groups, based on how much longer than expected their telomeres were. The group with the longest telomeres had 33 percent higher odds of developing any cancer than the group with the shortest telomeres, after taking into account the effect of age, sex, education, and smoking habits.
That group also had 66 percent higher odds of developing lung cancer, 39 percent higher odds of developing breast cancer, 55 percent higher odds of developing prostate cancer, and 37 percent higher odds of developing colorectal cancer.
Of all the cancers, pancreatic had the largest increase in incidence related to longer telomeres, with participants in the highest one-fifth for telomere length at nearly 2.6 times the odds of developing pancreatic cancer, compared to those in the lowest one-fifth for telomere length. Only the risk of liver cancer went down with longer telomeres.
For three cancers, the risk was greatest for both the groups with extreme short and extreme long telomeres—creating a “U-shaped” risk curve. Participants in the group with the shortest telomere length had 63 percent higher odds of stomach cancer, 72 percent higher odds of bladder cancer, and 115 percent higher odds of leukemia than the group in the middle of the curve. The group with the longest telomeres had 55 percent higher odds of stomach cancer, 117 percent higher odds of bladder cancer, and 68 percent higher odds of leukemia.
Source: www.futurity.org